Endocrine Abstracts

We report a 21-year-old man who referred to endocrinologist following biopsy of a left-sided cervical mass. The pathological examination was diagnostic for medullary thyroid carcinoma (MTC). Physical examination was remarkable for a firm 3-cm nodule in right thyroid lobe and another 3 cm. firm nontender mass in left thyroid lobe. The calcitonin was 15,324 pg/ml, and carcinoembryonic antigen was 415 ng/ml. The calcium level was 10.3 mg/dl (<10 mg/dl) with unsuppressed parat...

Neurofibromatosis type 1 (NF1) is a rare autosomal dominant disorder characterized by the development of multiple benign tumors of the nerves and the skin (neurofibromas) and areas of abnormal increased and decreased coloration of the skin. Pheochromocytoma develops in 0.1–5.7% of NF1 patients and plexiform neurofibroma in 30% of NF1 patients. We present a case of a 38-year-old female, without relevant personal, with a familial phenotype suggestive for NF1, evaluated for ...

Background: The surgical technique and the extent of thyroidectomy are related to parathyroid injury and hypoparathyroidism.Methods and results: We retrospectively analyzed the files of 552 patients who underwent thyroidectomy in our surgery department between 2015-2017 with the aim to assess the incidence and impact of intraoperative features that may predispose to postoperative hypoparathyroidism (PoSH).Results: 171 (30.97%) pati...

Introduction: BRAF V600E mutation is reported to occur in 28–83% of papillary thyroid cancer, being associated with increased tumour aggressiveness.Objective: To determine the prevalence of BRAF V600E mutation in Romanian patients with thyroid nodules referred to surgery in a reference endocrinology centre.Materials and methods: 140 patients were included in the study: 70 patients with papillary thyroid carcinoma (PTC), 42 pat...

Introduction: Primary hyperparathyroidism is typically caused by a parathyroid adenoma (80-85% of the cases). Very rare causes are represented by parathyroid carcinoma and atypical parathyroid adenoma (0.5-1.5% of the cases). Atypical parathyroid adenomas have atypical histological features, not sufficient to be considered a carcinoma, and have an uncertain malignant potential and risk of recurrence. We report the case of a 66-year-old man referred from another medical center ...

Objectives: Post-surgical hypoparathyroidism (PoSH) is a common long-term complication after thyroid surgery. The reported median incidence rates of temporary and permanent PoSH was 27% and 1% respectively.Methods and results: We retrospectively analyzed the files of 552 patients who underwent thyroidectomy in our surgery department between 2015 and 2017 with the aim to assess the prevalence of PoSH and to identify patient and disease related factors ass...

Background: The association between differentiated thyroid carcinoma (DTC) and autoimmune thyroiditis (AT) has been reported in numerous studies, yet the impact of the concurrent presence of AT and DTC remains controversial.Methods: We retrospectively analysed the files of 493 patients submitted to thyroidectomy in our surgery department between January 2012 and September 2015.Results: A total of 86 patients with DTC were enrolled,...

Background: The role of circulating Galectin-3 as a potential biomarker of malignancy in thyroid disease remains inconclusive. In a previous pilot study we reported a significant difference between serum Gal-3 levels in papillary thyroid carcinoma (PTC) patients and those with benign pathology, but no association with tumor aggressiveness.Aim: We measured serum Gal-3 levels in a larger series of patients submitted to thyroidectomy, in order to assess its...

Background: The role of inflammation in the pathogenesis of cancer and the mechanisms through which platelets can influence the aggressive behaviour of different types of cancer have been highlighted by a few studies.Methods: We retrospectively analysed the files of 493 patients submitted to thyroidectomy in our surgery department between 2012 and 2015. We assessed the relationship between differentiated thyroid cancer (DTC) and mean platelet volume (MPV...

Objectives: In recent studies, neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) are being investigated as prognostic and diagnostic markers for many malignancies, including thyroid cancer. The aim of our study was to investigate if a relationship exists between NLR and PLR and thyroid cancer.Materials and methods: We retrospectively analysed the files of 953 patients who underwent thyroidectomy in our surgery department between...